Article
The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse.
Genes & development - 15 Mar 1998
Gu Z, Nomura M, Simpson B B, Lei H, Feijen A, van den Eijnden-van Raaij J, Donahoe P K, Li E
Abstract excerpt
ActRIB is a type I transmembrane serine/threonine kinase receptor that has been shown to form heteromeric complexes with the type II activin receptors to mediate activin signal. To investigate the function of ActRIB in mammalian development, we generated ActRIB-deficient ES cell lines and mice by...
Topics
- Activin Receptors, Type I
- Animals
- Blastocyst
- Cell Line
- Embryo, Mammalian
- Embryonic Development
- Embryonic Induction
- Female
- Gastrula
- Gene Expression
- Genes
- Genes, Lethal
- Humans
- Mesoderm
- Mice
- Mice, Inbred C57BL