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Article

The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse.

Genes & development - 15 Mar 1998

Gu Z, Nomura M, Simpson B B, Lei H, Feijen A, van den Eijnden-van Raaij J, Donahoe P K, Li E

Abstract excerpt

ActRIB is a type I transmembrane serine/threonine kinase receptor that has been shown to form heteromeric complexes with the type II activin receptors to mediate activin signal. To investigate the function of ActRIB in mammalian development, we generated ActRIB-deficient ES cell lines and mice by gene targeting. Analysis of the ActRIB-/- embryos showed that the epiblast and the extraembryonic ectoderm were...

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Identifiers

PMID: 9512518
DOI: 10.1101/gad.12.6.844
PMCID: PMC316628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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