Article
The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo.
Development (Cambridge, England) - 1 Jun 1999
Gu Z, Reynolds E M, Song J, Lei H, Feijen A, Yu L, He W, MacLaughlin D T, van den Eijnden-van Raaij J, Donahoe P K, Li E
Abstract excerpt
ActRIA (or ALK2), one of the type I receptors of the transforming growth factor-beta (TGF-beta) superfamily, can bind both activin and bone morphogenetic proteins (BMPs) in conjunction with the activin and BMP type II receptors, respectively. In mice, ActRIA is expressed primarily in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation....
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