Different phenotypes for mice deficient in either activins or activin receptor type II.

doi:10.1038/374356a0

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Article

Different phenotypes for mice deficient in either activins or activin receptor type II.

Nature - 23 Mar 1995

Matzuk M M, Kumar T R, Bradley A

Abstract excerpt

Activins are believed to initiate a signal transduction cascade by binding to serine/threonine kinase receptors types I and II. Activins bind to several different receptors in vitro, but the significance of this interaction in vivo has not been confirmed. To test the function of the type II activin receptor (ActRcII) in mammalian development and reproduction, we generated a null mutation in the ActRcII gene in...

Topics

Activin Receptors
Activins
Animals
Cell Line
Embryonic and Fetal Development
Female
Follicle Stimulating Hormone
Gonads
Growth Substances
Inhibins
Male
Mandible

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Phenotype

Pituitary Gland, Anterior

Protein Serine-Threonine Kinases

Receptors, Growth Factor

Source

Open in PubMed

Identifiers

PMID: 7885474
DOI: 10.1038/374356a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7885474-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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