Article
Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2007
Goto Yutaka, Nomura Masatoshi, Tanaka Kimitaka, Kondo Akiyo, Morinaga Hidetaka, Okabe Taijirou, Yanase Toshihiko, Nawata Hajime, Takayanagi Ryoichi, Li En
Abstract excerpt
Signaling through activin type IIB receptor (ActRIIB) has been shown to regulate the axial formation and the development of foregut-derived organs such as the pancreas in mice. Here, we provide genetic evidence that ActRIIB and Smad2 genes cooperatively regulated asymmetrical patterning of the thoracic organs and pancreas development in mice. The loss of one allele of Smad2 on ActRIIB-/- background resulted in...
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