Article
The first oncogene in Drosophila melanogaster.
Mutation research - 1 Mar 1999
Baek K H
Abstract excerpt
Discovered by Bridges in the 1930s, lethal (2) giant larvae was the first of more than 27 recessive oncogenes identified in Drosophila, which provides an excellent model to study neoplastic mechanisms due to the fact that homologs of human oncogenes and tumor suppressors have been isolated and most of the complexes and associated pathways are conserved. This review explores the potential of neoplastic studies in...
Topics
- Amino Acid Sequence
- Animals
- Cell Communication
- Drosophila Proteins
- Drosophila melanogaster
- Genes, Insect
- Humans
- Insect Proteins
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Neoplasms