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Article

Increased type IV collagenase in lgl-induced invasive tumors of Drosophila.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1994

Woodhouse E, Hersperger E, Stetler-Stevenson W G, Liotta L A, Shearn A

Abstract excerpt

Loss of function mutations in the lethal giant larvae (lgl) gene causes neoplastic brain tumors in Drosophila. We have introduced a lacZ reporter gene into lgl mutant cells and used beta-galactosidase expression as a marker to monitor the growth of such tumors following transplantation into wild-type adult hosts. Whereas normal larval brains do not grow when transplanted, mutant brains can develop into enormous...

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PMID: 8180128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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