Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased type IV collagenase in lgl-induced invasive tumors of Drosophila.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1994

Woodhouse E, Hersperger E, Stetler-Stevenson W G, Liotta L A, Shearn A

Abstract excerpt

Loss of function mutations in the lethal giant larvae (lgl) gene causes neoplastic brain tumors in Drosophila. We have introduced a lacZ reporter gene into lgl mutant cells and used beta-galactosidase expression as a marker to monitor the growth of such tumors following transplantation into wild-...

Topics

Animals
Brain
Brain Neoplasms
Collagenases
Cross Reactions
Drosophila melanogaster
Electrophoresis, Polyacrylamide Gel
Gelatinases
Genes, Lethal
Humans
Immunoblotting
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Larva

Mutation

Neoplasm Invasiveness

Neoplasm Transplantation

Source

Identifiers

PMID: 8180128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8180128-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased type IV collagenase in lgl-induced invasive tumors of Drosophila.PMID 8180128Read ↗

Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes.Semantic proximity Read ↗

Metastatic ability of Drosophila tumors depends on MMP activity.Semantic proximity Read ↗

Tumorigenic Properties of <i>Drosophila</i> Epithelial Cells Mutant for <i>lethal giant larvae</i>Semantic proximity Read ↗

Drosophila invasive tumors: a model for understanding metastasis.Semantic proximity Read ↗

Ectopic expression of matrix metalloproteinases and filopodia extension via JNK activation are involved in the invasion of blood tumor cells in Drosophila mxc mutant.Semantic proximity Read ↗

Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype.Semantic proximity Read ↗

A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway.Semantic proximity Read ↗

Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila.Semantic proximity Read ↗

The expression of the Drosophila awd gene during normal development and in neoplastic brain tumors caused by lgl mutations.Semantic proximity Read ↗

Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A.Semantic proximity Read ↗

Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type IV collagenase leads to an invasive phenotype.Semantic proximity Read ↗

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.