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Article

Possible involvement of Escherichia coli 23S ribosomal RNA in peptide bond formation.

RNA (New York, N.Y.) - 1 Mar 1998

Nitta I, Ueda T, Watanabe K

Abstract excerpt

Experimental results are presented suggesting that 23S rRNA is directly involved in the peptide bond formation usually performed on the ribosome. Although several reports have indicated that the eubacterial peptidyltransferase reaction does not necessarily require all the ribosomal proteins, the reconstitution of peptidyltransferase activity by a naked 23S rRNA without the help of any of the ribosomal proteins...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9510328
PMCID: PMC1369615

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Possible involvement of Escherichia coli 23S ribosomal RNA in peptide bond formation.PMID 9510328Read ↗

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.Semantic proximity Read ↗

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451.Semantic proximity Read ↗

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit.Semantic proximity Read ↗

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.Semantic proximity Read ↗

Mutations at nucleotides G2251 and U2585 of 23 S rRNA perturb the peptidyl transferase center of the ribosome.Semantic proximity Read ↗

Non-stressful death of 23S rRNA mutant G2061C defective in puromycin reaction.Semantic proximity Read ↗

Mutations at position A960 of E. coli 23 S ribosomal RNA influence the structure of 5 S ribosomal RNA and the peptidyltransferase region of 23 S ribosomal RNA.Semantic proximity Read ↗

[Mutations in the Escherichia coli 23S rRNA increase the rate of peptidyl-tRNA dissociation from the ribosome].Semantic proximity Read ↗

Suppression of nonsense mutations induced by expression of an RNA complementary to a conserved segment of 23S rRNA.Semantic proximity Read ↗

Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase center.Semantic proximity Read ↗

Toward ribosomal RNA catalytic activity in the absence of protein.Semantic proximity Read ↗

Functional interactions within 23S rRNA involving the peptidyltransferase center.Semantic proximity Read ↗

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