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Article

Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase center.

RNA (New York, N.Y.) - 1 Feb 1998

Saarma U, Spahn C M, Nierhaus K H, Remme J

Abstract excerpt

Previous experiments have shown that the top of helix 90 of 23S rRNA is highly important for the ribosomal peptidyltransferase activity and might be part of the donor (P) site. Developing on these studies, mutations in the 23S rRNA at the highly conserved positions G2505, G2582, and G2583 were investigated. None of the mutations affected assembly, subunit association, or the capacity of tRNA binding to A and P...

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Identifiers

PMID: 9570318
PMCID: PMC1369607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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