Article
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
Cancer research - 1 Mar 1998
Zurawel R H, Chiappa S A, Allen C, Raffel C
Abstract excerpt
The beta-catenin, glycogen synthase kinase 3beta (GSK-3beta), and adenomatous polyposis coli (APC) gene products interact to form a network that influences the rate of cell proliferation. Medulloblastoma occurs as part of Turcot's syndrome, and patients with Turcot's who develop medulloblastomas have been shown to harbor germ-line APC mutations. Although APC mutations have been investigated and not identified in...
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