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Article

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

Cancer research - 1 Mar 1998

Zurawel R H, Chiappa S A, Allen C, Raffel C

Abstract excerpt

The beta-catenin, glycogen synthase kinase 3beta (GSK-3beta), and adenomatous polyposis coli (APC) gene products interact to form a network that influences the rate of cell proliferation. Medulloblastoma occurs as part of Turcot's syndrome, and patients with Turcot's who develop medulloblastomas...

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Source

Identifiers

PMID: 9500446

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9500446-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Sporadic medulloblastomas contain oncogenic beta-catenin mutations.PMID 9500446Read ↗

Control of beta-catenin/Tcf-directed transcription in medulloblastoma.Semantic proximity Read ↗

APC mutations in sporadic medulloblastomas.Semantic proximity Read ↗

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APC and CTNNB1 mutations are rare in sporadic ependymomas.Semantic proximity Read ↗

GLI3 is not mutated commonly in sporadic medulloblastomas.Semantic proximity Read ↗

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors.Semantic proximity Read ↗

The Molecular Basis of Turcot's SyndromeSemantic proximity Read ↗

Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma.Semantic proximity Read ↗

AXIN1 mutations but not deletions in cerebellar medulloblastomas.Semantic proximity Read ↗

Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.Semantic proximity Read ↗

Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.Semantic proximity Read ↗

Beta-catenin mutations in craniopharyngiomas and pituitary adenomas.Semantic proximity Read ↗

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