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Article

Nuclear localization and mutation of beta-catenin in medulloblastomas.

Journal of neuropathology and experimental neurology - 1 Apr 2000

Eberhart C G, Tihan T, Burger P C

Abstract excerpt

The adenomatous polyposis coli (APC) gene, a member of the Wingless/Wnt signal transduction pathway, has been implicated in the development of medulloblastomas in Turcot's syndrome. beta-catenin also functions in this highly conserved signaling pathway and is instrumental in growth and development. Mutations in either APC or beta-catenin can stabilize beta-catenin protein. Stabilized beta-catenin complexes with...

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Source

Identifiers

PMID: 10759189
DOI: 10.1093/jnen/59.4.333

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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