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Article

Control of beta-catenin/Tcf-directed transcription in medulloblastoma.

Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 May 2004

Raffel C

Abstract excerpt

The beta-catenin, glycogen synthase kinase 3beta (GSK-3beta), and adenomatous polyposis coli (APC) gene products interact to form a network that influences the rate of cell proliferation. Medulloblastoma occurs as part of Turcot's syndrome and patients with Turcot's syndrome, who develop medulloblastomas, have been shown to harbor germline APC mutations. While APC mutations have been investigated and not...

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Source

Identifiers

PMID: 15176713
DOI: 10.1111/j.1651-2227.2004.tb03049.x

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Control of beta-catenin/Tcf-directed transcription in medulloblastoma.PMID 15176713Read ↗

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.Semantic proximity Read ↗

Nuclear localization and mutation of beta-catenin in medulloblastomas.Semantic proximity Read ↗

APC mutations in sporadic medulloblastomas.Semantic proximity Read ↗

Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.Semantic proximity Read ↗

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.Semantic proximity Read ↗

Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus.Semantic proximity Read ↗

Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.Semantic proximity Read ↗

Mutational analysis of the beta-catenin gene in gastric carcinomas.Semantic proximity Read ↗

Beta-catenin gene analysis in oral squamous cell carcinoma.Semantic proximity Read ↗

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