Article
Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.
Genes, chromosomes & cancer - 1 Mar 1994
Mori T, Nagase H, Horii A, Miyoshi Y, Shimano T, Nakatsuru S, Aoki T, Arakawa H, Yanagisawa A, Ushio Y
Abstract excerpt
The Turcot syndrome (TS) is a rare, probably autosomal recessive, disorder characterized by development of primary neuroepithelial tumors of the central nervous system (CNS) and numerous adenomatous colorectal polyps. To examine the possible involvement of mutations of the APC gene, which is resp...
Topics
- Adenomatous Polyposis Coli
- Adult
- Astrocytoma
- Base Sequence
- Brain Neoplasms
- Breast Neoplasms
- Child, Preschool
- Female
- Genes, APC
- Glioblastoma
- Humans
- Male
- Medulloblastoma
- Molecular Sequence Data
- Mutation