Article
GLI3 is not mutated commonly in sporadic medulloblastomas.
Cancer - 1 Jul 2002
Erez Ayelet, Ilan Tsafra, Amariglio Ninette, Muler Inna, Brok-Simoni Frida, Rechavi Gideon, Izraeli Shai
Abstract excerpt
BACKGROUND: Medulloblastoma is a malignant, invasive embryonic tumor of the cerebellum. Sonic hedgehog (SHH) is a secreted glycoprotein that has a major role in the developing cerebellum. Activation of the SHH pathway resulting from mutations in the PATCH gene, which is an inhibitor of the pathway, are associated with hereditary and sporadic medulloblastomas. The GLI3 protein is another negative regulator of SHH...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.