Article
APC and CTNNB1 mutations are rare in sporadic ependymomas.
Cancer genetics and cytogenetics - 15 Jul 2006
Onilude Olabisi E, Lusher Meryl E, Lindsey Janet C, Pearson Andrew D J, Ellison David W, Clifford Steven C
Abstract excerpt
The ependymoma is the second most common malignant brain tumor of childhood; however, its molecular basis is poorly understood. The formation of multiple ependymomas has been reported as an occasional feature of Turcot syndrome type 2 (TS2), a familial cancer syndrome caused by inherited mutations of the APC tumor suppressor gene, and characterised by the concurrence of a primary CNS tumor (predominantly...
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