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Article

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.

Oncogene - 3 Jun 2004

Taylor Michael D, Zhang Xiaoyun, Liu Ling, Hui Chi-Chung, Mainprize Todd G, Scherer Stephen W, Wainwright Brandon, Hogg David, Rutka James T

Abstract excerpt

Germline mutations of APC in patients with Turcot syndrome (colon cancer and medulloblastoma), was well as somatic mutations of APC, beta-catenin, and Axin in sporadic medulloblastomas (MBs) have shown the importance of WNT signaling in the pathogenesis of MB. A subset of children with MB have ge...

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Source

Identifiers

PMID: 15077159
DOI: 10.1038/sj.onc.1207605

Genes

SUFU
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15077159-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.PMID 15077159Read ↗

Mutations in SUFU predispose to medulloblastoma.Semantic proximity Read ↗

Role and regulation of human tumor suppressor SUFU in Hedgehog signaling.Semantic proximity Read ↗

No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours.Semantic proximity Read ↗

Germline SUFU mutation carriers and medulloblastoma: clinical characteristics, cancer risk, and prognosisSemantic proximity Read ↗

Loss of suppressor-of-fused function promotes tumorigenesis.Semantic proximity Read ↗

Medulloblastoma: a problem of developmental biology.Semantic proximity Read ↗

Loss of SUFU function in familial multiple meningioma.Semantic proximity Read ↗

Nuclear localization and mutation of beta-catenin in medulloblastomas.Semantic proximity Read ↗

p53 and microRNA-34 are suppressors of canonical Wnt signaling.Semantic proximity Read ↗

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.Semantic proximity Read ↗

Identification of a<i>SUFU</i>germline mutation in a family with Gorlin syndromeSemantic proximity Read ↗

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.Semantic proximity Read ↗

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