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Article

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors.

International journal of cancer - 1 Aug 2001

Koch A, Waha A, Tonn J C, Sörensen N, Berthold F, Wolter M, Reifenberger J, Hartmann W, Friedl W, Reifenberger G, Wiestler O D, Pietsch T

Abstract excerpt

Primitive neuroectodermal tumors (PNETs) represent the most frequent malignant brain tumors in childhood. The majority of these neoplasms occur in the cerebellum and are classified as medulloblastomas (MB). Most PNETs develop sporadically; however, their incidence is highly elevated in patients carrying germline APC gene mutations. The APC gene encodes a central component of the WNT/wingless developmental...

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Source

Identifiers

PMID: 11433413
DOI: 10.1002/ijc.1342

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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