Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APC mutations in sporadic medulloblastomas.

The American journal of pathology - 1 Feb 2000

Huang H, Mahler-Araujo B M, Sankila A, Chimelli L, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

The cerebellar medulloblastoma (WHO Grade IV) is a highly malignant, invasive embryonal tumor with preferential manifestation in children. Several molecular alterations appear to be involved, including isochromosome 17q and the p53, PTCH, and beta-catenin gene mutations. In this study, 46 sporadic medulloblastomas were screened for the presence of mutations in genes of the Wnt signaling pathway (APC and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Adenomatous Polyposis Coli Protein
Share to Cerebellar Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to DNA, Neoplasm

Share to Medulloblastoma

Share to Polymorphism, Single-Stranded Conformational

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 10666372
DOI: 10.1016/S0002-9440(10)64747-5
PMCID: PMC1850060

Genes

APC
AGT
GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APC mutations in sporadic medulloblastomas.PMID 10666372Read ↗

Medulloblastomas associated with an APC germline pathogenic variant share the good prognosis of CTNNB1-mutated medulloblastomasSemantic proximity Read ↗

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors.Semantic proximity Read ↗

APC and CTNNB1 mutations are rare in sporadic ependymomas.Semantic proximity Read ↗

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.Semantic proximity Read ↗

Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors.Semantic proximity Read ↗

Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis.Semantic proximity Read ↗

AXIN1 mutations but not deletions in cerebellar medulloblastomas.Semantic proximity Read ↗

Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma.Semantic proximity Read ↗

Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.Semantic proximity Read ↗

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.Semantic proximity Read ↗

Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.Semantic proximity Read ↗

The Molecular Basis of Turcot's SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.