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Article

APC mutations in sporadic medulloblastomas.

The American journal of pathology - 1 Feb 2000

Huang H, Mahler-Araujo B M, Sankila A, Chimelli L, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

The cerebellar medulloblastoma (WHO Grade IV) is a highly malignant, invasive embryonal tumor with preferential manifestation in children. Several molecular alterations appear to be involved, including isochromosome 17q and the p53, PTCH, and beta-catenin gene mutations. In this study, 46 sporadi...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Open in PubMed Open full text

Identifiers

PMID: 10666372
DOI: 10.1016/S0002-9440(10)64747-5
PMCID: PMC1850060

Genes

APC
AGT
GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10666372-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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APC mutations in sporadic medulloblastomas.PMID 10666372Read ↗

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Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors.Semantic proximity Read ↗

APC and CTNNB1 mutations are rare in sporadic ependymomas.Semantic proximity Read ↗

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.Semantic proximity Read ↗

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AXIN1 mutations but not deletions in cerebellar medulloblastomas.Semantic proximity Read ↗

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Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.Semantic proximity Read ↗

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