Analysis of in vivo mutation in exon 8 of the rat hprt gene.

doi:10.1016/0027-5107(94)90082-5

Back to search

Article

Analysis of in vivo mutation in exon 8 of the rat hprt gene.

Mutation research - 1 Nov 1994

Mittelstaedt R A, Heflich R H

Abstract excerpt

We have analyzed mutations in exon 8 of the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in T-lymphocytes from the spleens of ethylnitrosourea-treated female rats. Presumptive hprt- mutants were isolated by clonal growth in the presence of 6-thioguanine. DNA from 6-thioguanine-resis...

Topics

Animals
Base Sequence
DNA Primers
Exons
Female
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Rats

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.