Article
Genomic organization and mutational analysis of the human UCP2 gene, a prime candidate gene for human obesity.
Journal of receptor and signal transduction research - 1 Jan 2000
Lentes K U, Tu N, Chen H, Winnikes U, Reinert I, Marmann G, Pirke K M
Abstract excerpt
Uncoupling proteins (UCPs) are mitochondrial membrane transporters which are involved in dissipating the proton electrochemical gradient thereby releasing stored energy as heat. This implies a major role of UCPs in energy metabolism and thermogenesis which when deregulated are key risk factors for the development of obesity and other eating disorders. Recent studies have shown that the sympathetic nervous system,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.