Article
Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.
Diabetologia - 1 Dec 2000
Cassell P G, Saker P J, Huxtable S J, Kousta E, Jackson A E, Hattersley A T, Frayling T M, Walker M, Kopelman P G, Ramachandran A, Snehelatha C, Hitman G A, McCarthy M I
Abstract excerpt
AIMS/HYPOTHESIS: Uncoupling proteins are mitochondrial transmembrane carriers implicated in the regulation of energy balance. Dysfunction of UCP3 (the predominant uncoupling protein in skeletal muscle) might therefore be expected to reduce thermogenic capacity, alter energy homeostasis and influence predisposition to obesity and Type II (non-insulin-dependent) diabetes mellitus. A variant in the putative promoter...
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