Article
Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study.
Molecular medicine (Cambridge, Mass.) - 1 Jul 2001
Lanouette C M, Giacobino J P, Pérusse L, Lacaille M, Yvon C, Chagnon M, Kuhne F, Bouchard C, Muzzin P, Chagnon Y C
Abstract excerpt
BACKGROUND: UCP3 is a mitochondrial membrane transporter that is postulated to uncouple oxidative phosphorylation from ATP synthesis producing heat instead of ATP. Human UCP3 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, UCP3 is a good candidate gene for obesity. MATERIALS AND METHODS: We analyzed, among 734 subjects from the Québec...
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