Article
[Biological effects of arsenic and diseases: The mechanisms involved in arsenic-induced carcinogenesis].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jul 2016
Suzuki Takehiro, Takumi Shota, Okamura Kazuyuki, Nohara Keiko
Abstract excerpt
Chronic arsenic exposure is associated with many diseases, including cancers. Our study using in vivo assay in gpt-delta transgenic mice showed that arsenic particularly induces G : C to T : A transversions, a mutation type induced through oxidative-stress-induced 8-OHdG formation. Gestational arsenic exposure of C3H mice was reported to increase hepatic tumor incidence. We showed that gestational arsenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
