[Plasmid pBR322 drug-resistance gene changes induced by glycidyl methacrylate].

Article

[Plasmid pBR322 drug-resistance gene changes induced by glycidyl methacrylate].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Aug 1991

Fang F

Abstract excerpt

A mutagen, glycidyl methacrylate (GMA), discovered by us a few years ago has been used to investigate the mutation mechanism of drug-resistance genes of plasmid pBR322. The results indicated that GMA binds strongly to pBR322 DNA, and this binding decreased the relative transformation efficiency u...

Topics

Ampicillin Resistance
Epoxy Compounds
Methacrylates
Mutation
R Factors
Tetracycline Resistance

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