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Article

Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.

Immunity - 1 Feb 1998

Hande S, Notidis E, Manser T

Abstract excerpt

We analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune response of mice in which Bcl-2 expression was enforced in B cells. Many of the antibodies expressed by the arsonate-induced memory compartment of these mice were "dual-reactive," displaying increased affinity acquired via V region somatic hypermutation for both arsonate and the autoantigen DNA. The hypermutated antibodies...

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Identifiers

PMID: 9492000
DOI: 10.1016/s1074-7613(00)80471-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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