Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1 Oct 1991

Abstract excerpt

The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an immunoglobulin heavy chain enhancer (E mu). Mice of a representative transgenic strain, E mu-bcl-2-22, had a great excess of B lymphocytes, immunoglobulin-secreting cells, and serum immunoglobulins, attributable to increased longevity of B-lineage cells. Pre-B and plasma cells as well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunodeficiency and Autoimmune Disorders
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1924327
DOI: 10.1073/pnas.88.19.8661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.PMID 1924327Read ↗

The combined effect of BCL-2 over-expression and E2F2 deficiency induces an autoimmune syndrome in non-susceptible mouse strain C57BL/6.Semantic proximity Read ↗

Bcl-2 leads to expression of anti-DNA B cells but no nephritis: a model for a clinical subsetSemantic proximity Read ↗

Differential effects of Bcl-2 on T and B cells in transgenic mice.Semantic proximity Read ↗

Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production.Semantic proximity Read ↗

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.Semantic proximity Read ↗

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Semantic proximity Read ↗

Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemiaSemantic proximity Read ↗

Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.Semantic proximity Read ↗

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude AutoimmunitySemantic proximity Read ↗

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.Semantic proximity Read ↗

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypesSemantic proximity Read ↗

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.