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Article

Bcl-2 leads to expression of anti-DNA B cells but no nephritis: a model for a clinical subset

1 Oct 1999

Abstract excerpt

Transgenic mice expressing anti-DNA antibodies have been extensively studied as a model for understanding B cell regulation in systemic lupus erythematosus (SLE). BALB/c mice transgenic for the R4A-gamma2b heavy chain of an anti-double-stranded DNA (dsDNA) antibody produce two populations of high-affinity anti-dsDNA B cells, one deleted, and the other anergized. We generated double-transgenic BALB / c mice...

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Identifiers

PMID: 10540328
DOI: 10.1002/(sici)1521-4141(199910)29:10<3168::aid-immu3168>3.0.co;2-h

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