Article
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.
eLife - 2 Sept 2014
Burger Megan L, Leung Kenneth K, Bennett Margaux J, Winoto Astar
Abstract excerpt
T cell self-tolerance is thought to involve peripheral tolerance and negative selection, involving apoptosis of autoreactive thymocytes. However, evidence supporting an essential role for negative selection is limited. Loss of Bim, a Bcl-2 BH3-only protein essential for thymocyte apoptosis, rarely results in autoimmunity on the C57BL/6 background. Mice with T cell-specific over-expression of Bcl-2, that blocks...
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