Article
Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations.
Psychopharmacology - 1 Aug 2005
Hwang Rudi, Shinkai Takahiro, De Luca Vincenzo, Müller Daniel J, Ni Xingqun, Macciardi Fabio, Potkin Steven, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L
Abstract excerpt
RATIONALE: Dopamine D(2) receptor blockade is the major basis for the antipsychotic action of typical antipsychotic drugs (AP) and a necessary but not sufficient basis for the antipsychotic action of atypical APs such as clozapine and other multireceptor antagonists which rely, in part, upon 5-HT(2A) antagonism. Genetic factors affecting the density and/or function of D(2) receptors may therefore affect AP...
Topics
- Adult
- Black or African American
- Alleles
- Antipsychotic Agents
- Clozapine
- Drug Resistance
- Drug Tolerance
- Female
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium