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Article

Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response

1 Dec 1998

Abstract excerpt

Dopamine receptors are strong candidates for involvement in schizophrenia and are targeted by a wide variety of antipsychotics. We hypothesized that genetic variation in these neurotransmitter receptors may influence clinical response to clozapine, an antipsychotic which displays high affinity for dopamine D2 receptors in the limbic system. To test this hypothesis, we studied a functional polymorphism in the...

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PMID: 9918131
DOI: 10.1097/00008571-199812000-00004

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