Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.

The American journal of psychiatry - 1 Aug 1996

Malhotra A K, Goldman D, Ozaki N, Breier A, Buchanan R, Pickar D

Abstract excerpt

OBJECTIVE: The authors' goal was to determine whether either of two 5-HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response. METHOD: Brief Psychiatric Rating Scale (BPRS) ratings were obtained in 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genetic Variation
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Share to Psychiatric Status Rating Scales

Share to Schizophrenia

Source

Identifiers

PMID: 8678181
DOI: 10.1176/ajp.153.8.1092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.PMID 8678181Read ↗

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response.Semantic proximity Read ↗

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.Semantic proximity Read ↗

Association between clozapine response and allelic variation in 5-HT2A receptor gene.Semantic proximity Read ↗

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients.Semantic proximity Read ↗

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia.Semantic proximity Read ↗

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.Semantic proximity Read ↗

No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population.Semantic proximity Read ↗

Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine responseSemantic proximity Read ↗

5-HT2 receptor gene locus: association with schizophrenia or treatment response not detected.Semantic proximity Read ↗

Genetic variation of 5-HT2A receptor and response to clozapine.Semantic proximity Read ↗

Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia.Semantic proximity Read ↗

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.