Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.

doi:10.1176/ajp.153.8.1092

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Article

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.

The American journal of psychiatry - 1 Aug 1996

Malhotra A K, Goldman D, Ozaki N, Breier A, Buchanan R, Pickar D

Abstract excerpt

OBJECTIVE: The authors' goal was to determine whether either of two 5-HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response. METHOD: Brief Psychiatric Rating Scale (BPRS) ratings were obtained in 70 patients with schizophrenia or schizoaffective disorder to...

Topics

Adult
Alleles
Clozapine
Female
Genetic Variation
Genotype
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Psychiatric Status Rating Scales
Psychotic Disorders
Receptor, Serotonin, 5-HT2A
Receptors, Serotonin
Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 8678181
DOI: 10.1176/ajp.153.8.1092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8678181-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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