Article
Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response.
Schizophrenia research - 1 Nov 2002
Gutiérrez Blanca, Arranz María J, Huezo-Diaz Patricia, Dempster David, Matthiasson P, Travis M, Munro Janet, Osborne Sarah, Kerwin Robert W
Abstract excerpt
Clozapine is a potent antagonist of 5-HT3 receptors, which are ligand-gated ion channels that mediate rapid excitatory responses in the central nervous system. Two different isoforms of 5-HT3 receptor subunit genes (HTR3A and HTR3B) have been identified. They have been assigned to chromosome 11q23.1-q23.2, a region which in the past has been linked to schizophrenia and bipolar disorder. In this study, we...
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