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Article

Association between clozapine response and allelic variation in 5-HT2A receptor gene.

Lancet (London, England) - 29 Jul 1995

Arranz M, Collier D, Sodhi M, Ball D, Roberts G, Price J, Sham P, Kerwin R

Abstract excerpt

We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter...

Topics

Alleles
Base Sequence
Clozapine
DNA Primers
Female
Genetic Variation
Genotype
Homozygote
Humans
Male
Molecular Sequence Data
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Receptor, Serotonin, 5-HT2A

Receptors, Serotonin

Schizophrenia

Source

Identifiers

PMID: 7630250
DOI: 10.1016/s0140-6736(95)92168-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7630250-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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