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Article

Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle.

Annals of neurology - 1 Feb 1998

Brierley E J, Johnson M A, Lightowlers R N, James O F, Turnbull D M

Abstract excerpt

It has been proposed that one mechanism for nerve and muscle dysfunction with age involves the mitochondria. Mitochondria contain the only DNA outside the nucleus in mammalian cells. Mitochondrial DNA (mtDNA) has a high mutation rate, and low levels of pathogenic mutations have been found in tiss...

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Identifiers

PMID: 9485063
DOI: 10.1002/ana.410430212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9485063-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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