Mitochondrial DNA mutations and ageing.

doi:10.1016/j.bbagen.2009.04.018

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Article

Mitochondrial DNA mutations and ageing.

Biochimica et biophysica acta - 1 Oct 2009

Greaves Laura C, Turnbull Doug M

Abstract excerpt

The mechanism by which we age has sparked a huge number of theories, and is an area of intense debate. As the elderly population rises, the importance of elucidating these mechanisms is becoming more apparent as age is the single biggest risk factor for a number of diseases such as cancer, diabetes and neurodegenerative disease. Mitochondrial DNA (MtDNA) mutations have been shown to accumulate in cells and...

Topics

Aging
Animals
DNA, Mitochondrial
Gene Deletion
Humans
Mice
Mitochondrial Diseases
Mitochondrial Proteins
Models, Animal
Mutation

Source

Open in PubMed

Identifiers

PMID: 19409965
DOI: 10.1016/j.bbagen.2009.04.018

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