Article
Mitochondrial DNA mutations and oxidative damage in aging and diseases: an emerging paradigm of gerontology and medicine.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences - 1 Apr 1998
Wei Y H
Abstract excerpt
Human mitochondrial DNA (mtDNA) is a multi-copy extra-chromosomal genetic element, which is exposed to a high steady-state level of reactive oxygen species and free radicals generated by the respiratory chain in mitochondria. Thus, it is much more vulnerable to oxidative damage and mutation than...
Topics
- Aging
- DNA, Mitochondrial
- Geriatrics
- Humans
- Mitochondrial Myopathies
- Models, Biological
- Mutation
- Oxidative Stress
- Reactive Oxygen Species