Article
Mitochondrial abnormalities in muscle and other aging cells: classification, causes, and effects.
Muscle & nerve - 1 Nov 2002
DiMauro Salvatore, Tanji Kurenai, Bonilla Eduardo, Pallotti Francesco, Schon Eric A
Abstract excerpt
The involvement of mitochondria and of mitochondrial DNA (mtDNA) in the aging process has generated much interest and even more controversy. The mitochondrial theory of aging considers a vicious circle consisting of: (1) accumulation of somatic mtDNA mutations; (2) impairment of respiratory chain function; (3) increased production of reactive oxygen species (ROS) in mitochondria; and (4) further damage to mtDNA....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.