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Mitochondrial DNA in aging and degenerative disease.

Mutation research - 18 Apr 2001

Berdanier C D, Everts H B

Abstract excerpt

The mitochondrial DNA encodes only a few gene products compared to the nuclear DNA. These products, however, play a decisive role in determining cell function. Should this DNA mutate spontaneously or be damaged by free radicals the functionality of the gene products will be compromised. A number of mitochondrial genetic diseases have been identified. Some of these are quite serious and involve the central nervous...

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PMID: 11295162
DOI: 10.1016/s0027-5107(01)00068-9

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