Article
Role of mitochondrial DNA mutations in disease and aging.
Annals of the New York Academy of Sciences - 1 Jun 2000
Cottrell D A, Blakely E L, Borthwick G M, Johnson M A, Taylor G A, Brierley E J, Ince P G, Turnbull D M
Abstract excerpt
Since Harman in 1972 first proposed a role in the process of aging for the mitochondrial genome, a wealth of evidence has been accumulated to support this theory. We discuss the hereditary mitochondrial DNA disorders, which we believe may give insight into both normal aging and neurodegenerative conditions. We then review the evidence for the role of mitochondrial DNA mutations in both aging and age-related...
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