Article
Mitochondrial DNA mutations in disease and ageing.
Novartis Foundation symposium - 1 Jan 2001
Cottrell D A, Blakely E L, Johnson M A, Borthwick G M, Ince P I, Turnbull D M
Abstract excerpt
The chronological accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. We discuss the evidence behind this theory and relate some of the ageing mitochondrial changes to mitochondrial DNA disorders. In particular, we describe the aggregation of cytochrome c oxidase-deficient cells in both skeletal muscle and the CNS...
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