Article
Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents.
British journal of cancer - 1 Feb 1998
Iwadate Y, Tagawa M, Fujimoto S, Hirose M, Namba H, Sueyoshi K, Sakiyama S, Yamaura A
Abstract excerpt
Astrocytic tumours often become resistant to a variety of chemotherapeutic agents in advanced stages and frequently possess mutations in the p53 tumour-suppressor gene. Previous studies using established cell lines to investigate the relation between mutated p53 genes and altered resistance to an...
Topics
- Antineoplastic Agents
- Astrocytoma
- Brain Neoplasms
- DNA, Neoplasm
- Drug Resistance, Neoplasm
- Flow Cytometry
- Genes, p53
- Humans
- Microtubules
- Mutation
- Polymorphism, Single-Stranded Conformational