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Article

Multifaceted resistance of gliomas to temozolomide.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2002

Bocangel Dora B, Finkelstein Sydney, Schold S Clifford, Bhakat Kishor K, Mitra Sankar, Kokkinakis Demetrius M

Abstract excerpt

PURPOSE AND EXPERIMENTAL DESIGN: The contributions of O6-methylguanine-DNA-methyltransferase(MGMT), p53 status, mismatch repair, and apoptotic response to the resistance of glial tumors to temozolomide (TMZ) were tested using seven established human glial tumor cell lines in culture and xenografts in athymic mice. RESULTS: Resistance to TMZ was only marginally dependent on MGMT activity, because subtoxic doses of...

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PMID: 12171906

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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