Article
Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas.
International journal of cancer - 21 Jun 1996
Iwadate Y, Fujimoto S, Tagawa M, Namba H, Sueyoshi K, Hirose M, Sakiyama S
Abstract excerpt
Loss of p53 function is involved in tumorigenesis of various human cancers, but the relation between mutation of the p53 tumor-suppressor gene and the chemo- and radiosensitivity of tumors remains unclear. Mutated p53 gene in malignant glioma is often associated with progression and recurrence of...
Topics
- Adolescent
- Adult
- Aged
- Antineoplastic Agents
- Apoptosis
- Base Sequence
- Brain Neoplasms
- DNA, Neoplasm
- Drug Screening Assays, Antitumor
- Female
- Flow Cytometry
- Genes, p53
- Glioma
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation