Article
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.
International journal of cancer - 18 Dec 1998
Weller M, Rieger J, Grimmel C, Van Meir E G, De Tribolet N, Krajewski S, Reed J C, von Deimling A, Dichgans J
Abstract excerpt
Less than 30% of malignant gliomas respond to adjuvant chemotherapy. Here, we asked whether alterations in the p53 and RB pathways and the expression of six BCL-2 family proteins predicted acute cytotoxicity and clonogenic cell death induced by BCNU, vincristine, cytarabine, teniposide, doxorubic...
Topics
- Antineoplastic Agents
- Apoptosis
- Brain Neoplasms
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Genes, Retinoblastoma
- Genes, p53
- Glioma
- Humans
- Mutation
- Proto-Oncogene Proteins c-bcl-2
- Tumor Cells, Cultured