Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteasome inhibitors potentiate etoposide-induced cell death in human astrocytoma cells bearing a mutated p53 isoform.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2006

Ceruti Stefania, Mazzola Alessia, Abbracchio Maria P

Abstract excerpt

Resistance to anticancer agents is often due to defects of intracellular pathways of cell death. Thus, the identification of the apoptotic pathways that can still be recruited by chemotherapeutic agents in cancerous cells can disclose new opportunities to treat malignancies. Here we show that human astrocytoma ADF cells (which are resistant to "mitochondriotropic" agents as well as to the antineoplastic drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Astrocytoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspases

Share to Etoposide

Share to Membrane Potentials

Share to Proteasome Endopeptidase Complex

Share to RNA, Neoplasm

Share to Subcellular Fractions

Source

Identifiers

PMID: 16971507
DOI: 10.1124/jpet.106.109397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteasome inhibitors potentiate etoposide-induced cell death in human astrocytoma cells bearing a mutated p53 isoform.PMID 16971507Read ↗

Hyperthermia induces translocation of apoptosis-inducing factor (AIF) and apoptosis in human glioma cell lines.Semantic proximity Read ↗

Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.Semantic proximity Read ↗

Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.Semantic proximity Read ↗

Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells.Semantic proximity Read ↗

Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells.Semantic proximity Read ↗

Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents.Semantic proximity Read ↗

The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependentSemantic proximity Read ↗

Etoposide induces cell death via mitochondrial-dependent actions of p53Semantic proximity Read ↗

Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.Semantic proximity Read ↗

Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines.Semantic proximity Read ↗

Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.Semantic proximity Read ↗

Alterations of the p53 and pRB pathways in human astrocytoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.