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Article

Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.

Cancer biology & therapy - 1 Mar 2009

Sato Yuichi, Kurose Akira, Ogawa Akira, Ogasawara Kuniaki, Traganos Frank, Darzynkiewicz Zbigniew, Sawai Takashi

Abstract excerpt

Phosphorylation of histone H2AX is a sensitive marker of DNA damage, particularly of DNA double strand breaks. Using multiparameter cytometry we explored effects of etoposide and temozolomide (TMZ) on three glioblastoma cell lines with different p53 status (A172, T98G, YKG-1) and on normal human astrocytes (NHA) correlating the drug-induced phosphorylated H2AX (gammaH2AX) with cell cycle phase and induction of...

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Identifiers

PMID: 19305157
DOI: 10.4161/cbt.8.5.7740
PMCID: PMC3855308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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