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Article

The combination of two Sle2 lupus-susceptibility loci and Cdkn2c deficiency leads to T-cell-mediated pathology in B6.Fas(lpr) mice.

Genes and immunity - 1 Sept 2013

Xu Z, Croker B P, Morel L

Abstract excerpt

The NZM2410 Sle2c1 lupus susceptibility locus is responsible for the expansion of the B1a cell compartment, and for the induction of T-cell induced renal and skin pathology on a CD95-deficient (Fas(lpr)) background. We have previously shown that deficiency in the cyclin-dependent kinase inhibitor p18(INK4c) (p18) was responsible for the B1a cell expansion but was not sufficient to account for the pathology in...

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Identifiers

PMID: 23698709
DOI: 10.1038/gene.2013.28
PMCID: PMC3752316

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