Article
B cell maturation and selection at the marrow-periphery interface.
Immunologic research - 1 Jan 1998
Cancro M P, Allman D M, Hayes C E, Lentz V M, Fields R G, Sah A P, Tomayko M
Abstract excerpt
More than 95% of newly formed B cells die in the short interval spanning sIgM acquisition in the bone marrow and entry into the long-lived pool, suggesting that selective events dictating B cell longevity occur at this stage. These likely include both ligand-induced deletion as well as discrete events that mediate recruitment to the long-lived recirculating pool. We are probing these events through the...
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