Article
Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma.
Journal of cutaneous medicine and surgery - 1 Jan 1998
Hogg D, Brill H, Liu L, Monzon J, Summers A, From L, Lassam N J
Abstract excerpt
BACKGROUND: Approximately 8 to 12% of melanoma appears to be inherited in an autosomal dominant form. Although most early stage melanomas can be treated successfully by simple surgical excision, patients with advanced disease are rarely cured even with aggressive chemotherapy and/or immunotherapy. OBJECTIVE: There is now compelling evidence that germline mutations of the CDKN2A gene on chromosome 9p21 predispose...
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