Article
Rarity of CDK4 germline mutations in familial melanoma.
Melanoma research - 1 Feb 2002
Goldstein A M, Chidambaram A, Halpern A, Holly E A, Guerry IV D, Sagebiel R, Elder D E, Tucker M A
Abstract excerpt
To date, two genes have been implicated in melanoma pathogenesis. The first, CDKN2A, is a tumour suppressor gene with germline mutations detected in 20% of melanoma-prone families. The second, CDK4, is an oncogene with co-segregating germline mutations detected in only three kindreds worldwide. We examined 16 American melanoma-prone families for mutations in all coding exons of CDK4 and screened additional...
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