Article
Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample.
Journal of the National Cancer Institute - 19 Oct 2005
Begg Colin B, Orlow Irene, Hummer Amanda J, Armstrong Bruce K, Kricker Anne, Marrett Loraine D, Millikan Robert C, Gruber Stephen B, Anton-Culver Hoda, Zanetti Roberto, Gallagher Richard P, Dwyer Terence, Rebbeck Timothy R, Mitra Nandita, Busam Klaus, From Lynn, Berwick Marianne
Abstract excerpt
BACKGROUND: Germline mutations in the CDKN2A gene have been linked to melanoma incidence in many families with multiple cases of the disease. Previous studies of multiple-case families have indicated that the lifetime risk (i.e., penetrance) of melanoma in CDKN2A mutation carriers is very high, ranging from 58% in Europe to 91% in Australia by age 80 years. In this study, we examined lifetime melanoma risk among...
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